Graviola or Soursop is an evergreen flowering plant that grows along the areas of Central America, Caribbean, Brazil, Peru, South East Asia, along Mauritius and the Sahara.

It grows mostly along the highly humid regions and can resist only moderate temperatures and warm winters. The Graviola is popularly known for its potent ability to cure cancer.

The fruit and the leaves serve a variety of purposes to treat various diseases. The fruit is rich in Vitamin C, Vitamin B1 and B2 and can be used as a supplement in case of these deficiencies.

The Graviola tree is known by the biological name – Annona muricata.

Graviola for Cancer

It has not yet been proven cent percent still, based on many laboratory tests, Graviola showed good results when employed to cure liver and breast cancer. Graviola works on the cancer cells and destroys them by limiting the cell signaling between the tumor cells.

Graviola reduces the secretion of the ATP in the cell and by this way the energy supply to the cell is cut and the cell is destroyed.

Graviola has not yet been implemented or approved for human trials, but it has been tested on various animals and the studies showed positive results.

Even though there were so many studies, it was proved that graviola can only be used as a supplement for chemotherapy to cure cancer and cannot be used as a sole source of treatment.

Some of the studies for cancer are reported below and are still under research and investigation.

Cancer cells were extracted from an infected organism and were subjected to 75µg of a crude leaf extract of Annona muricata.

The experiment was carried in – vitro and they were incubated and it was proven to reduce the effect of the cancer cells and inhibit their multiplication by reducing the NADH oxidase.

This was due to the presence of Acetogenins and Phytochemicals like Anonaine, Friedelin, Isolaureline, Annonamine, Anomurine, Kaempferol, Asimilobine, Quercetin, Xylopine which were the prime ones responsible for the reduction of the effect of the NADH oxidase.

It is further being tested and being implemented in various animal species for further investigation.

Another factor responsible for cancer is an oncogene receptor known as Epidermal Growth Factor (EFGR) is the one that is responsible for the proliferation of the cancer cells.

Human breast cancer cells were taken and were cultured in a Petri dish (In – vitro study). Graviola fruit extract (GFE) was taken and was inoculated into these cells. It was found that the Graviola fruit extract subsequently lowered the EFGR genetic expression there by reducing the rate of the proliferation of the cancer cells.

The same GFE was then injected into a xenograft of mice and then studies were carried out and similar positive results were obtained proving that graviola can be a standalone cure for cancer.

This was due to the inhibiting of the EFGR /ERK cell signaling pathway. Hence this proved that graviola can be effective for cancer.

Further to the above research study, toxicity and cancer studies were done on mice. Cancer cells were infiltrated into the mice dermis layer of the skin to test whether graviola is effective for skin cancer. Groups of mice were examined with different dosages.

The one with the highest dosage showed great resistance to the cancer cells and it had inhibited the proliferation and this proves that graviola was able to suppress the growth and proliferation of the cancer cells.

Apart from these, pancreatic cancer cells were examined and an in vitro study was carried out. After extraction of these pancreatic cells, they were subjected to graviola extract. C

ytotoxicity and cell metabolism studies were carried out and due to the expression of the following genes HIF-1α, NF-κB, GLUT1, GLUT4, HKII, and LDHA, necrosis of the pancreatic cells took place and the cell metabolism of the cancer cells reduced thereby reducing the proliferation of the cancer cells. This showed that Graviola can be an anti cancer agent.

A very rare research study of cancer in the head and neck was also carried out. It was estimated that out of the total different types of cancer, 8% of it was head and neck carcinoma. Graviola was reported to be an active cure for this type of cancer as investigated by Dr.Barry .R. Casselith.

Some studies related to Vaginal carcinoma was also reported but it accounts to 1 or 2% of the total cancers caused and graviola was found to be used for that treatment also but the results are yet unstable and that side of research still remains pretty much dark.

Dosage

The cost of Graviola is more than £5 for 100 capsules. The manufacturers advise taking 2 capsules, 3 to 4 times a day. So, 100 capsules could last less than 2 weeks which obviously is cheaper than chemotherapy.

The dosage basically has to be consulted with an oncologist as it varies from person to person with respect to their weight. The average dosage is 100 – 200 mg /kg/ per day.

Graviola can not only be taken in the form of capsules, but also as juice, syrup, essence.

Most of them take graviola in the form of tea as it is known to cause lesser side effects. Proper dosage at proper intervals and at the right proportion can eliminate side effects and can be of good medicinal value.

Precautions

The most important factor is that it cannot be used by pregnant and nursing women as it disturbs the uterine cycle and causes hormonal imbalance.

Prolonged intake can damage the digestion friendly bacteria present in the digestive tract. It can also cause improper bowel movement which in turn can cause issues related to digestion while higher dosages can lead to nausea and vomiting.

It can cause damage to the nervous system by disrupting the neurotransmitter signals. Due to this, patients can develop Parkinson’s or Alzheimer’s.

It is a cardio depressant and can help lower the blood pressure levels hence people having lower pressure are not advised to take Graviola and Known to cause dilation of the blood vessels – Vasodilation.

The leaves of Annona muricaata contains little amounts of hydro – cyanide which is poisonous and cannot be consumed over a period of time.

It should not be combined with anti depressing agents as it promotes the secretion of CoA which works against the anti depressing agents.

Summary

The benefits and the case studies for graviola in treatment of cancer are mentioned above and its side effects are also mentioned.

Even though so many results have been reported and proven, still the FDA has not approved Graviola for the treatment of cancer and human trials have not been approved due to the various side effects reported.

It is always advised to consult an oncologist to cure cancer before resorting to further treatment.

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