Quick Answer: Best Chitosan
Chitosan is a type of fiber derived from the outer cover or shells of crustacean species like shrimps, crabs, lobster, etc. Recently chitosan gained popularity as a weight loss aid and to lower cholesterol.  
It has many pharmaceutical uses too like wound healing, anti-inflammatory, gum-disease, insomnia, etc.  
It is also used as the filler in many capsules, and as a drug delivery carrier in order to control the way certain drugs dissolve; and to mask bitter tastes.    
How does it work?
Chitosan fiber when moving through the intestines binds to the fat present in the intestine and carries it along out of the body, preventing it from being absorbed back into the body.  
Chitosan shows a potent anti-microbial effect especially on gram-negative bacteria owing to its ability to dissolve and break the outer cell membrane of the bacteria which ultimately leads to the death of the bacteria.  
Comparison of Top Chitosan Supplements
Here is a quick comparison of the top chitosan supplements in the market today.
Bulksupplements Chitosan[amazon fields="B01MTO38EL" value="thumb" image_size="medium" image_align="center"]
Best in Powder
|1,000 mg Powder Packet||Lab tested|
Best Naturals -- Chitosan[amazon fields="B00KPXAC28" value="thumb" image_size="medium" image_align="center"]
Best in Capsules
|500 mg, 120 capsules||Made in USA|
Now Foods Chitosan[amazon fields="B018KV8H7I" value="thumb" image_size="medium" image_align="center"]
|500 mg, 120 capsules||Has Chromium|
Reviews of the Best Chitosan Powder
Here are the reviews of the best Chitosan Powder available in the Market today.
Bulk Supplements Chitosan Powder[amazon fields="B01MTO38EL" value="thumb" image_size="large" image_align="center"] Bulk Supplements is among the most popular brands in the health supplement world.
The Nevada-based company has as many as four hundred natural products sold at affordable prices.
Bulk Supplements chitosan powder is clean, pure and 100-percent organic.
Chitosan is a natural fiber sourced from shells of crustaceans such as crabs, lobsters, shrimps, etc.
It aids healthy weight management, lowers the level of bad cholesterol while raising the level of HDL.
It also prevents constipation and promotes digestive health in general.
This supplement is better taken along with ascorbic acid to enhance its health benefits.
It is lab-tested for purity and packaged in a resealable pouch to keep out possible contaminants.
Pros and Cons
- Mixes well
- It is very pure
- Good for weight loss
- Taste could be better
Best Naturals Chitosan 500mg Tablets[amazon fields="B00KPXAC28" value="thumb" image_size="large" image_align="center"]
Headquartered in New Jersey, United States, Best Naturals is dedicated to manufacturing a wide range of premium-quality supplements such as vitamins, essential oils, herbal products, minerals, etc.
Best Naturals offers high-quality chitosan supplement in an easy-to-take tablet form.
A pill supplies the body with 500mg pure chitosan, a dietary fiber obtained from crustaceans’ shells.
This supplement is highly prized for its unique ability to support weight loss, lower LDL (bad cholesterol) levels and support digestive health.
It can also be used to treat or prevent constipation, as it adds to stool bulk and promotes bowel regularity.Key constituents of the supplements –
Pros and Cons
- Easy to swallow
- No artificial ingredients
- Great price
- Aids weight loss
- Some customers complained that it makes them gassy
NOW Foods Chitosan 500mg 120 Capsules[amazon fields="B018KV8H7I" value="thumb" image_size="large" image_align="center"]
NOW is a trusted and renowned nutrition company established in the late 1960s. The brand has a line of high-quality natural products, including protein powder, maca, probiotics, among others.
One capsule of this supplement delivers 500mg of pure chitosan, a popular weight loss supplement gotten from shells of crustaceans like lobsters, crabs, etc.
It contains no additional ingredients – no fillers, additives, GMOs or preservatives. Chitosan helps relieve constipation, reduces the levels of bad cholesterol, and prevents weight gain.
Pros and Cons
- Contains no fillers, or preservatives
- Easy to swallow
- Good price
- Help with constipation
- It may cause diarrhea or stomach upset in some cases
Health Benefits of Chitosan
Here are some of the key health benefits of Chitosan.
1. Chitosan may help protect the nervous system
The anti-inflammatory and anti-oxidative properties along with several chelating properties of chitosan may help prevent Alzheimer’s Disease (AD), Parkinson’s disease (PD), Huntington's disease (HD), and Nerve Injury.
Confidence level: High
The brain is the most vulnerable organ with the restricted ability of self-repair if and when injured.
Mechanisms and strategies that help protect against any brain or central nervous system injury is termed as neuroprotection system.
The recent medicines or the synthetic neuroprotective agents have several side-effects and thus a natural neuroprotective drug with little to no side-effect is the need of an hour.
Recently, chitosan has gained a lot of attention as an all-natural neuroprotective agent.
Chitosan demonstrates a potent inhibition of the beta-amyloid cleavage enzyme (BACE-1) activity.
This enzyme is responsible for the development as well as the progression of Alzheimer’s disease (AD).  
There are few test-tube studies reporting that chitosan helps prevent oxidative stress and cytotoxicity in the brain caused by infection and/or due to drug overuse.    
Some studies showed that chitosan can stop neurons from dying and inhibit tau protein formation thus, blocking the AD progression.   
In animal studies with Parkinson’s disease, it was demonstrated that chitosan can inhibit brain cells from dying (apoptosis), protect the mitochondrial membrane potential (MMP), and relieve oxidative stress. 
Similar results were found in animal studies for Huntington disease, chitosan can reduce the oxidative stress on the central nervous system (CNS). 
Scientists propose that chitosan and its derivatives may help control Multiple Sclerosis (MS) as they can help repair the damaged myelin sheath fibers, nerve damage, traumatic brain injuries, and the damaged spinal cord neurons by initiating the neural stem cell differentiation.   
Several test-tube studies show that chitosan can combine with almost all the neurotrophic factors in the human body that can help with nerve cell regeneration.     
2. Chitosan has potent antimicrobial properties
Chitosan can restrict the growth of many multi-drug resistant pathogens including bacteria, fungi, viruses, and phages without increasing resistance. It is widely used as a wound dressing ointment to help repair the wound as well as protect against microbial infection. It is also used as a preservative in many packaged food.
Confidence Level: High
Infections and infestation is not only major concerns in the pharmaceutical industry but in the food industry too.
There are more than 1100 studies published so far reporting the antibacterial activity of chitosan and its derivatives.
Chitosan has been traditionally used as an ointment for wound healing owing to anti-inflammatory and anti-microbial properties. 
The exact mechanism is still uncertain although scientists proposed that chitosan can bind to the outer cell membrane of the bacteria thus destroying it protective barrier and causing its death.     
Some test-tube studies also demonstrate chitosan’s anti-fungal properties against common urinary tract infection (UTI) causing fungi like C. albicans, Candida krusei, and Candida glabrata.  
It has been suggested that chitosan and its derivatives suppress viral infections and block the replication of the virulent phage in both plants and animal models.
There are few experiments showing that a chitosan derivative (N-carboxymethylchitosan-N,O-sulfate) can stop the reproduction of HIV-1 in mouse cell lines.     
Although there are very few human trials most of them show promising results in-effect with chitosan’s antimicrobial activity.
3. Chitosan helps in healing and tissue regeneration
Chitosan and its derivatives have been commonly used for its tissue regenerating and wound healing properties such as in patients undergoing plastic surgery. It can interact with the skin stem cells, helping in rapid wound healing. It has many applications in the field of tissue engineering.
Confidence level: High
Tissue engineering consists of reconstructing or regenerating damaged biological tissue in situations such as lesions, infections, and traumas.
Tissue engineering approaches generally involve using a combination of cells, bioactive molecules, and biomaterials.  
Chitosan is considered to be the only natural polysaccharide with the ability to bond with mucous tissue, termed as mucoadhesiveness, this property has spiked great interest in tissue engineering research.    
Chitosan with platelet-rich plasma (PRP) has been shown to improve joint muscle pain and cartilage repair in an animal study. 
Chitosan is also useful for bone regeneration.  
As mentioned above it helps expedite the wound repair after surgery as it can increase the stem cell production in the skin.     
Chitosan has been effectively used to treat nerve grafts and may also prevent diabetic ulcers.  
Chitosan and CHOS help boost collagen and hyaluronic acid production in the skin thus helps prevent scarring.
Few studies showed that using the chitosan and honey together significantly increased the healing process of the burn wounds in animal models.  
Chitosan has been used as a bonding agent or cementing agent to help close punctured lungs and blood vessels to avoid any hemorrhages.  
Chitosan owing to its potent anti-microbial property can also lower the chances of wound infections. 
4. Chitosan can aid in weight loss journey
Recently, chitosan is hyped as a weight loss aid. Most of the research shows that chitosan along with a low-calorie diet results in a small amount of weight loss. But taking chitosan without restricting calories intake does nothing to improve weight loss.
In short, chitosan can help with weight loss in overweight and obese people only if paired with a restricted calorie diet and exercise.
Confidence level: Medium
A 24-week long clinical with 250 participants conducted at the University of Auckland showed that although the chitosan group lost more body weight as opposed to the placebo group.
But statistically, the differences were very small when compared to the placebo group. 
Results obtained from a total of fifteen different research studies with a total of 1219 participants showed a very insignificant effect of chitosan on the weight loss and were unlikely to be of any clinical significance.   
On a contrary, a study conducted in overtly obese and overweight patients supplemented with 3 grams of chitosan daily for 12-weeks showed a significant decrease in their LDL cholesterol level. 
Another study for the two-week period, treating eight normal weight adult males, with chitosan showed that cholesterol intake decreased from 340 to 276 mg/day.
Although the results were not that significantly longer treatment duration is needed to confirm chitosan effectiveness. 
Another mode of action demonstrated in animal studies is that chitosan can produce a highly viscous gel in the stomach thus increasing the satiety this may result into decreased food intake. 
5. Chitosan can help in the drug delivery system
The biodegradability and biocompatibility properties of chitosan and its derivatives make them perfect candidates for an oral as well as a sub-cutaneous drug delivery system. These polysaccharides are deemed extremely malleable and non-toxic substitutes to the current synthetic and harmful drug delivery agents.  
Confidence level: Medium
Chitosan can improve the structural as well as chemical stability and enhance the therapeutic effects of several medicinal compounds like insulin, hormones, chemotherapy drugs, gene delivery, antioxidants, antibiotics, vitamins, food supplements, and vaccines.       
For example, chitosan can enhance the delivery of probiotics containing live strains of Lactobacillus acidophilus, Lactobacillus rhamnosus, Lactobacillus reuteri, and/or Bifidobacterium Longum.  
6. Chitosan may be used as an alternative anti-cancer treatment
Chitosan and its derivatives are top runners as chemotherapy and radiotherapy alternatives for many drug-resistant tumors.
Confidence level: Medium
Cancer is the second most common cause of death after heart disease, and according to the World Health Organization the death toll may cross 10 million people by 2020. 
The current age conventional anti-cancer drugs generally produce severe side effects like reducing the patients’ immunity and energy to fight against the cancer and infections.
Therefore, it is important to find new, powerful anticancer agents that are highly effective but also with little to none side-effects.
Chitosan have been reported to selectively break into the cancer cells and kill them by various physiological actions. 
As discussed above chitosan can help boost the drug delivery system as well as improve the effectiveness of chemo-and radio-therapies.
It has been proven effective against multi-drug resistant cancers    
Test-tube studies have shown that chitosan can also restrict the development and progression of various types of cancer cells. It can also make these cancer cells more sensitive to radiotherapy.    
Most of the studies supplementing chitosan for weight loss study used dosage between 2 to 3 grams per day for a short term ranging from 7 days to 12 weeks.
It is always advisable to consult with an expert or a doctor before starting these supplements or any other dietary supplements.
Possible Side Effects
Chitosan is considered safe for most people when taken orally or when applied to the skin for a short time. Care should be taken for those allergic to shellfish.
But it is known that most people allergic to shellfish are actually allergic to it meat and not the outer shell itself, so there is some divided views regarding the same.
Research shows constipation and upset stomach as possible side effects of chitosan.
In certain cases, it may impact the absorption of calcium and vitamins A, D, E, and K.
Chitosan may interfere with blood thinners like warfarin as well as some antiviral and diabetes medications.
There are some rare cases reporting of arsenic poisoning caused by long-term use of chitosan supplements.
Due to a lack of research, it is advisable to restrict supplementing chitosan in children, pregnant and/or breastfeeding women.
Does chitosan work for weight loss?
As mentioned above chitosan has mixed results with respect to weight-loss aid. Most of the studies confirm that chitosan only helps in weight-loss when combined with controlled calorie intake diet and exercise. But taking chitosan without cutting calories, doesn't improve weight loss.
Kindly refer the above section to learn more about its mode of actions.
Can chitosan lower creatinine levels?
Chitosan is believed to be effective in kidney disease and kidney failure.
In a small clinical trial 80 patients with kidney failure receiving ongoing hemodialysis treatment, half of the patients were given 1,500 mg of chitosan daily for 12 weeks and the other half did not receive any supplement.
The data from this study showed a significant decrease in urea and creatinine levels. Although the exact mode of action is still unknown and requires more investigation.
What is the difference between chitin and chitosan?
Chitin is the building material of which the outer shells of crustaceans (shellfish), insects, and the cell walls of certain fungi are made up of.
Upon enzymatic or chemical deacetylation, chitin is converted to chitosan.
Chitin has no known medical or industrial uses, Chitosan and its other derivatives, on the other hand, are well-known for their innumerable uses and applications.
Does chitosan cause constipation?
Chitosan is a long-chain polymer and difficult to digest. The most common side effects associated with chitosan supplementation are constipation, vomiting, cramping, and nausea.
The higher the fats content in the diet, the worse these side effects are. Other instances reported overdosage of chitosan.
In the end..
Chitosan has several health benefits and taking supplements is one way to get those benefits. Check out the list of the best Chitson supplements below, you can click on the links to check the specs, reviews, and offers from Amazon -
- Bulksupplements Chitosan - Best in Powder
- Best Naturals - Chitosan - Best in Capsules
- Now Foods Chitosan